Immunoregulatory and immunotherapeutic potential of mesenchymal stem/stromal cells: prospects and problems
AbstractMesenchymal stem cells (MSCs) have complex mechanisms of interaction with the immune system and are able to modulate innate and adaptive immune responses, as well as enhance angiogenesis. MSCs produce a variety of cytokines and chemokines that affect immune cell activity, inflammation and immune tolerance. Exosomes derived from MSCs also affect immune regulation. However, additional research and clinical trials are needed to fully exploit the therapeutic potential of MSC.
Keywords:mesenchymal stromal (or stem) cells; immunomodulation; extracellular vesicles; stem cell therapy; clinical trials
For citation: Bekhalo V.A., Gorskaya Yu.F., Nesterenko V.G. Immunoregulatory and immunotherapeutic potential of mesenchymal stem/stromal cells: prospects and problems. Immunologiya. 2024; 45 (3): 385–95. DOI: https://doi.org/10.33029/1816-2134-2024-45-3-385-395 (in Russian)
Funding. The study had no sponsor support.
Conflict of interests. Authors declare no conflict of interests.
Authors’ contribution. Concept development and planning, literature search and extraction, data synthesis, text writing – Bekhalo V.A.; responsibility for the integrity of all parts of the review – Gorskaya Yu.F.; editing, approval of the final version of the manuscript – Nesterenko V.G.
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