Genetic markers of response to cyclosporine treatment in psoriasis patients
AbstractThe aim of the present study was to assess the association rs3213619, rs2229109, rs1128503, rs2032582 single-nucleotide polymorphisms (SNPs) in the ABCB1 gene with response to cyclosporine treatment in Russian patients with psoriasis. DNA samples were collected from 168 patients with psoriasis. Genotyping of rs3213619, rs2229109, rs1128503, rs2032582 SNPs in the ABCB1 gene was performed by real-time polymerase chain reaction using the CFX 96™ RealTime Cycler (BioRad, USA). The variant rs1045642 in the ABCB1 gene showed an association with a negative response to cyclosporine therapy (OR = 2.58, 95% CI = 1.64-4.06). Further, larger studies are required to confirm our findings and replicate them in various populations.
Keywords:pharmacogenetics; psoriasis; ABCB1 gene; P-glycoprotein; polymorphic variants; association
For citation: Kilina D.A., Karnishkina O.Yu., Smirnova T.S., Galimova E.S. Genetic markers of response to cyclosporine treatment in psoriasis patients. Immunologiya. 2019; 40 (6): 22-5. doi: 10.24411/0206-4952-2019-16003
Funding. The study was carried out with the support of state contract no. P011. 0701 dated 17.04.2018, as well as within the framework of a grant from the European Union - the European regional development fund.
Conflict of interests. The authors declare no conflict of interests.
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